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| Outcomes Of Cifn And Rbv Therapy For Chronic Hep C G3 Patients Who Relapsed With Previous Peg-Interferon And Riba Therapy | | Uzma Adeeb1, Fatima Khatak1, Muzzaffar Gill1 | | 1 Maroof international hospital F 10 markaz islamabad, F 10 markaz islamabad | Aims and objectives: There are no published studies about the efficacy of Consensus interferon and Riba combination in chronic hepatitis C(G3) relapsers wiith Peginterferon Riba combination therapy. To evaluate the efficacy of consensus interferon and Ribavirin in patients previously treated with Pegylated interferon and Ribavirin combination therapy. We consecutively enrolled 20 patients with chronic hepatitis C G3 who relapsed with previous treatment with Pegylated interferon for atleast 6 months.
Methods: The study was conducted between Feb 2009 to September 2009.
Inclusion criteria: chronic hepatitis C G3 relapsers patients with documented history of Pegylated interferon and Ribavirin therapy for 6 months.
Exclusion criteria: active psychiatric history, platelet count < 75000, INR > 1.5, S. Albumin < 2.5, portal vein diameter > 13mm on ultrasound and active ischemic heart disease.
All enrolled patients have CBC, ALT, HCV PCR quantitative, HCV genotype, thyroid function tests .and blood sugar. .Patients were given 15ug thrice weekly consensus interferon and Ribavirin 400mg bid.The treatment duration was for 6 months. Patients were reviewed 4 weekly basis for clinical examination and CBC. We did check HCV PCR quantitative @week 12.. The patients who had HCV PCR negative or 50% reduction in HCV PCR at week 12 were given further 3 months of therapy.
Results: Among 20 patients 15 were male and 5 were female. Median age was 45.Median viral load was 900,000 IU/ml .Sixteen out of 20 (80%) patients were HCVPCR negative @ week 12 of therapy. These 16 patients completed further 12 weeks of therapy and remained HCVPCR negative @end of total 24 weeks of therapy.Two patients required filgrastin to keep neutrophil count in normal range.
Conclusion: Consensus interferon (infergen ) Ribavirin combination is very optimistic option for HEP C G3 relapsers with Peg Interferon Riba combination. Further studies are needed to confirm/refute these observation.. We did give 6 months of therapy because of financial consideration. |
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